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OAS2 Rabbit pAb (A17428)

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ABclonal:Western blot - OAS2 Polyclonal Antibody (A17428)

Overview

Product nameOAS2 Rabbit pAb
Catalog No.A17428
RRIDAB_2770708
Host speciesRabbit
Purification methodAffinity purification
IsotypeIgG
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2', 5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 600-700 of human OAS2 (NP_058197.2).
SequenceTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEPTGDVGGGDRWCWHLLAKEAKEWLSSPCFKDGTGNPIPPWKVPTMQTPGSCGARIHPIVN
Gene ID4939
Swiss protP29728
SynonymsOAS2
Calculated MW19kDa/78kDa/82kDa
Observed MW72kDa
ReactivityHuman
Tested applicationsWBIHCICCIF/ICCIPChIPChIP-seqRIPFCELISAMeDIPNucleotide ArrayDBFACSCoIPCUT&TagmeRIP
Recommended dilution
  • WB 1:500 - 1:2000
Storage bufferStore at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.
Application keyWestern blotting    
Positive samplesRaji
Cellular locationCytoplasm, Endoplasmic reticulum, Microsome, Mitochondrion, Nucleus, perinuclear region
    ABclonal:Western blot - OAS2 Polyclonal Antibody (A17428) }

    Western blot - OAS2 Polyclonal Antibody (A17428)

    Western blot analysis of extracts of Raji cells, using OAS2 antibody (A17428) at 1:1000 dilution.
    Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
    Lysates/proteins: 25ug per lane.
    Blocking buffer: 3% nonfat dry milk in TBST.
    Detection: ECL Basic Kit (RM00020).
    Exposure time: 30s.

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