變種新冠肺炎病毒來襲-COVID-19 D641G

by on April 16,2021


新冠肺炎病毒(COVID-19)自問是以來已經造成全球約50萬人死亡,一直以來科學家無不擔憂快速變種的病毒是否會造成第二波全球危機,而變種病毒的研究也是全球科學家關注的重點之一,近來已經有較可靠的科學證據證實新冠肺炎病毒的突變株-D641G會增加病毒的傳播能力。

D641G指的是新冠肺炎病毒表面Spike protein的第641位置由早期的天門冬胺酸(Aspartic acid, Asp, D)突變為甘胺酸(Glycine, Gly, G),這樣的突變會造成病毒Spike protein結構上的改變而與宿主細胞的結合更加穩固,因而加強感染能力讓病毒的傳播能力與適應能力增加,另外,根據世界各地的病毒種類分布與臨床研究也皆顯示D641G的存在優勢逐漸變強。拜爾國際(BioAb)的戰略夥伴ABclonal也率先推出了COVID-19 D614G的重組蛋白質,期望協助台灣的科學家與產業先進一同抵禦變種新冠肺炎病毒。


 ▶ Recombinant SARS-CoV-2 Spike S1(D614G) Protein with with His tag (RP01287)


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參考文獻:

1. Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus

2. Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2

3. The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity

4. Mutated coronavirus shows significant boost in infectivity

5. The pandemic virus is slowly mutating. But is it getting more dangerous?

6. D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity

7. Naturally mutated spike proteins of SARS-CoV-2 variants show differential levels of cell entry

8. The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types